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Exploring the Addressability of DNA Decorated Multifunctional Gold Nanoparticles with DNA Origami Template
Bioconjugate Chemistry ( IF 4.7 ) Pub Date : 2018-07-16 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00418
Rachel Nixon , Wenyan Liu , Shuo Yang , Risheng Wang

The hybridization of gold nanoparticles (AuNPs), along with other nanomaterials, has encouraged applications in biomedical imaging, plasmonic enhancement, and catalysts. However, the rational organization of AuNPs in nanotechnology fields remains difficult, which might require multiaddressability of nanoparticles for heterogeneous conjugation. In this work, multifunctional AuNPs were developed by conjugation of two types of DNA strands containing different sequences, which allowed the AuNPs to recognize multiple binding sites. The ratio of different sequences of DNA, and the different lengths of coding DNA oligos on the surface of the AuNPs, had varied influences on the functionality of the multifunctional DNA-AuNPs. This new type of DNA-decorated nanoparticles will enhance the diversity and complexity of nanoparticle-based bottom-up fabrication in materials science and bionanotechnology.

中文翻译:

DNA折纸模板探索DNA装饰的多功能金纳米粒子的可寻址性

金纳米颗粒(AuNPs)与其他纳米材料的杂交促进了在生物医学成像,等离子体增强和催化剂中的应用。但是,在纳米技术领域中合理地组织AuNPs仍然很困难,这可能需要纳米粒子的多寻址能力才能实现异质共轭。在这项工作中,通过结合两种包含不同序列的DNA链来开发多功能AuNP,从而使AuNP能够识别多个结合位点。DNA的不同序列的比率以及AuNPs表面上编码的DNA寡核苷酸的长度不同,对多功能DNA-AuNPs的功能有不同的影响。
更新日期:2018-07-16
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