Published data suggest that dietary-derived phenolics exert beneficial effects against hyperglycemia-mediated diseases, such as diabetes, through inhibiting the formation of advanced glycation endproducts (AGEs) and carbohydrate hydrolyzing enzyme activities. In the course of our investigation on the edible berry, Eugenia jambolana (known as Jamun), 21 phenolics (1–21) were isolated and identified from its seeds. Among these, one compound (1) is new and eleven compounds (3, 6, 9–13, 17, and 19–21) are being reported from E. jambolana for the first time. The anti-AGE activities of thirteen pure isolates (2–7, 9–12, 14, 15, and 20) were either comparable or superior to the synthetic anti-glycation agent, aminoguanidine, at three test concentrations (20, 50, and 100 μM) in the BSA–fructose assay. Most of these phenolics with anti-AGE activity exhibited potent free radical scavenging activity in the DPPH assay, and attenuated intracellular levels of LPS-induced reactive oxygen species in RAW264.7 macrophage. In addition, compounds 2–6, and 14 showed superior α-glucosidase inhibitory activity (IC₅₀ = 5.0–21.2 μM) compared to the clinical α-glucosidase inhibitor, acarbose (IC₅₀ = 289.9 μM). This is the first report of the anti-AGE effects of compounds 2–6 and 9–12, and α-glucosidase inhibitory activities of compounds 3–6, 9, 11 and 14. The current study supports the role of phenolics in the antidiabetic properties attributed to this edible berry, and warrants further animal studies to evaluate their potential as dietary agents for the prevention and/or therapy of hyperglycemia-mediated diseases.

中文翻译：

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来自Eugenia jambolana种子的酚类，具有先进的糖基化终产物形成和α-葡萄糖苷酶抑制活性

已发表的数据表明，饮食中的酚类药物通过抑制晚期糖基化终产物（AGEs）的形成和碳水化合物水解酶的活性，对高血糖介导的疾病（例如糖尿病）发挥有益作用。在我们对食用浆果Eugenia jambolana（被称为Jamun）的调查过程中，从种子中分离出21种酚类化合物（1-21）。在这些之中，一种化合物（1）是新的和11份的化合物（3，6，9-13，17，和19-21）正被从报告E. jambolana首次。十三种纯分离物的抗衰老活性（2-7，9-12，14，15，和20）要么相当或优于合成的抗糖化剂，氨基胍，在BSA-果糖测定三个测试浓度（20，50，和100μM）。这些具有抗AGE活性的酚类化合物大多数在DPPH分析中表现出有效的自由基清除活性，并减弱RAW264.7巨噬细胞中LPS诱导的活性氧物种的细胞内水平。此外，化合物2-6和14与临床α-葡萄糖苷酶抑制剂阿卡波糖（IC ₅₀）相比，具有更好的α-葡萄糖苷酶抑制活性（IC ₅₀ = 5.0-21.2μM）。= 289.9μM）。这是化合物的抗AGE效果的第一次报告2-6和9-12，和化合物的α葡萄糖苷酶抑制活性3-6，9，11和14。当前的研究支持酚类物质在归因于这种可食用浆果的抗糖尿病特性中的作用，并需要进行进一步的动物研究，以评估其作为预防和/或治疗高血糖介导的疾病的饮食剂的潜力。