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Tailored surface silica nanoparticles for blood-brain barrier penetration: preparation and in vivo investigation
Arabian Journal of Chemistry ( IF 6 ) Pub Date : 2018-09-01 , DOI: 10.1016/j.arabjc.2018.03.019
B.I. Tamba , V. Streinu , G. Foltea , A.N. Neagu , G. Dodi , M. Zlei , A. Tijani , C. Stefanescu

Abstract Surface modified fluorescent silica nanoparticle derivatives (Ru@SNPs), namely, glucose (Glu) and glucose-poly (ethylene glycol) methyl ether amine (Glu-PEG) coated SNPs were designed and tested for their ability to penetrate the blood-brain barrier (BBB) in mice brain. The new obtained nanoparticles were characterized by field emission scanning electron microscope (FE-SEM), dynamic light scattering (DLS) and Fourier transform infrared (FTIR-ATR) analysis. The BBB penetration and distribution of tailored SNPs in mice brain were examined using confocal laser scanning microscopy (CLSM), flow cytometer (FACS) and transmission electron microscopy (TEM). The promising results obtained by in vivo experiments, point out that silica nanoparticle derivatives are an efficient permeable delivery vehicle that are able to cross the BBB and reach the brain tissues via specific and non-specific mechanisms. These findings will enrich the knowledge to rationally engineer multifunctional nanoparticles, and bring new insights into BBB permeability.

中文翻译:

用于血脑屏障渗透的定制表面二氧化硅纳米粒子:制备和体内研究

摘要 设计了表面修饰的荧光二氧化硅纳米粒子衍生物(Ru@SNPs),即葡萄糖(Glu)和葡萄糖-聚(乙二醇)甲醚胺(Glu-PEG)包被的SNPs,并测试了它们穿透血脑的能力。小鼠大脑中的屏障(BBB)。新获得的纳米粒子通过场发射扫描电子显微镜(FE-SEM)、动态光散射(DLS)和傅里叶变换红外(FTIR-ATR)分析进行表征。使用共聚焦激光扫描显微镜 (CLSM)、流式细胞仪 (FACS) 和透射电子显微镜 (TEM) 检查了小鼠大脑中定制 SNP 的 BBB 渗透和分布。体内实验获得的有希望的结果,指出二氧化硅纳米颗粒衍生物是一种有效的可渗透递送载体,能够通过特定和非特定机制穿过 BBB 并到达脑组织。这些发现将丰富知识以合理设计多功能纳米粒子,并为 BBB 渗透性带来新的见解。
更新日期:2018-09-01
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