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A novel and convenient oxidation-controlled procedure for the synthesis of oxazolines from TosMIC and aldehydes in water – Anti biofilm activity
Arabian Journal of Chemistry ( IF 6 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.arabjc.2018.03.022
Rajan Abraham , Periakaruppan Prakash , Karthikeyan Mahendran , Murugappan Ramanathan

Abstract A new convenient procedure for the synthesis of oxazolines from tosylmethyl isocyanide (TosMIC) and aldehydes using imidazole as an efficient catalyst has been reported. The synthesized oxazolines were able to be protected from the oxidation by using just water both as a good solvent and anti oxidant. All the synthesized compounds show good anti biofilm activity against Staphylococcus epidermidis.

中文翻译:

从水中的 TosMIC 和醛类合成恶唑啉的一种新颖且方便的氧化控制程序 - 抗生物膜活性

摘要 已经报道了使用咪唑作为有效催化剂从甲苯磺酰甲基异氰化物 (TosMIC) 和醛合成恶唑啉的新方法。通过仅使用水作为良好溶剂和抗氧化剂,合成的恶唑啉能够防止氧化。所有合成的化合物对表皮葡萄球菌均表现出良好的抗生物膜活性。
更新日期:2020-01-01
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