Abstract The interaction of capecitabine (CAP) with cucurbit[7]uril (Q[7]) and inverted cucurbit[7]uril (iQ[7]) was investigated using nuclear magnetic resonance, fluorescence spectroscopy, MALDI-TOF mass spectrometry and isothermal titration calorimetry. The obtained results revealed that the alkyl chain of CAP is located inside the cavities of Q[7] or iQ[7], whereas the other section of CAP remains outside the portal. Our results suggest that both Q[7] and iQ[7] could be promising candidates for excipients used in medicinal and pharmaceutical research fields.

中文翻译：

---

卡培他滨与葫芦[7]脲和倒葫芦[7]脲的超分子药物包合物

摘要 使用核磁共振、荧光光谱、MALDI-TOF 质谱和等温法研究了卡培他滨 (CAP) 与葫芦 [7] 脲 (Q[7]) 和倒葫芦 [7] 脲 (iQ[7]) 的相互作用。滴定量热法。获得的结果表明，CAP 的烷基链位于 Q[7] 或 iQ[7] 的腔内，而 CAP 的另一部分保留在门户之外。我们的研究结果表明，Q[7] 和 iQ[7] 都可能是用于医药和药物研究领域的赋形剂的有希望的候选者。