Chemoresistance remains a major complication of cancer treatments. Recent data provide strong evidence that chemoresistance is linked to epithelial-mesenchymal transition (EMT), a latent developmental process, which is re-activated during cancer progression. EMT involves transcriptional reprogramming and is driven by specific EMT transcription factors (EMT-TFs). In this review, we provide support for the idea that EMT-TFs contribute to the development of resistance against cancer therapy and discuss how EMT-TFs might be targeted to advance novel therapeutic approaches to the treatment of cancer.

中文翻译：

---

上皮间质转化诱导转录因子：解决癌症化学耐药性的新靶点？

化学抗性仍然是癌症治疗的主要并发症。最近的数据提供了强有力的证据，证明化学抗性与上皮-间质转化（EMT）有关，这是一种潜在的发育过程，在癌症进展过程中会重新激活。EMT涉及转录重编程，并由特定的EMT转录因子（EMT-TF）驱动。在这篇综述中，我们为EMT-TFs促进抗癌治疗的发展提供了支持，并讨论了如何将EMT-TFs靶向用于推进新型的癌症治疗方法。