Reduced seasonal influenza vaccine effectiveness (VE) was observed in individuals who received repeated annual vaccinations. Preexisting influenza antibody levels were also found inversely correlated with postvaccination titers. These reports suggest that preexisting immunity may affect contemporary seasonal vaccine performance.

中文翻译：

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重复的甲型/ H3流感暴露对抗体数量和抗体质量的印记：对季节性疫苗株选择和疫苗性能的影响

在每年重复接种疫苗的个体中观察到季节性流感疫苗效力（VE）降低。还发现预先存在的流感抗体水平与疫苗接种后效价呈负相关。这些报告表明，先前存在的免疫力可能会影响当代季节性疫苗的性能。