Prior research has indicated that as an important biomarker of chronic low-grade inflammation, high-sensitivity C-reactive protein (hs-CRP) can play important roles on the onset of metabolic syndrome and cardiovascular diseases (CVD). We conducted an integrative approach, which combines biological wet-lab experiments, statistical analysis, and semantics-oriented bioinformatics & computational analysis, to investigate the association among hs-CRP, body fat mass (FM) distribution, and other cardiometabolic risk factors in young healthy women. Research outcomes in this study resulted in two novel discoveries. Discovery 1: There are four primary determinants for hs-CRP, i.e., central/abdominal FM (a.k.a. trunk FM) accumulation, leptin, high density lipoprotein cholesterol (HDL-C), and plasminogen activator inhibitior-1 (PAI-1). Discovery 2: Chronic inflammation may involve in adipocyte-cytokine interaction underlying the metabolic derangement in healthy young women.

中文翻译：

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研究年轻健康女性高敏感 C 反应蛋白、体脂肪量分布和其他心脏代谢危险因素之间关联的综合方法

先前的研究表明，作为慢性低度炎症的重要生物标志物，高敏C反应蛋白（hs-CRP）在代谢综合征和心血管疾病（CVD）的发生中发挥重要作用。我们进行了一种综合方法，结合了生物湿实验室实验、统计分析和面向语义的生物信息学和计算分析，以研究 hs-CRP、体脂肪量 (FM) 分布和其他心脏代谢危险因素之间的关联。健康的女性。本研究的研究成果产生了两个新发现。发现 1： hs-CRP 有四个主要决定因素，即中枢/腹部 FM（又名躯干 FM）积累、瘦素、高密度脂蛋白胆固醇 (HDL-C) 和纤溶酶原激活剂抑制剂-1 (PAI-1)。发现2：