The focus of this review is the basic methodology for applications of static deuteron NMR for studies of dynamics in the side chains of proteins. We review experimental approaches for the measurements of static line shapes and relaxation rates as well as signal enhancement strategies using the multiple echo acquisition scheme. Further, we describe computational strategies for modeling jump and diffusive motions underlying experimental data. Applications are chosen from studies of amyloid fibrils comprising the amyloid-β protein.

中文翻译：

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用于表征蛋白质侧链动力学的 2 H 静态核磁共振基本实验

本综述的重点是应用静态氘核 NMR 研究蛋白质侧链动力学的基本方法。我们回顾了使用多重回波采集方案测量静态线形状和弛豫率的实验方法以及信号增强策略。此外，我们描述了用于模拟实验数据基础上的跳跃和扩散运动的计算策略。应用程序选自包含淀粉样蛋白-β 蛋白的淀粉样蛋白原纤维的研究。