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Efficient Binding, Protection, and Self-Release of dsRNA in Soil by Linear and Star Cationic Polymers
ACS Macro Letters ( IF 5.8 ) Pub Date : 2018-07-12 00:00:00 , DOI: 10.1021/acsmacrolett.8b00420 Richard Whitfield 1 , Athina Anastasaki 1 , Nghia P Truong 2 , Alexander B Cook 1 , Marta Omedes-Pujol 3 , Vanessa Loczenski Rose 3 , Tuan A H Nguyen 4 , James A Burns 3 , Sébastien Perrier 1, 2, 5 , Thomas P Davis 1, 2 , David M Haddleton 1, 2
ACS Macro Letters ( IF 5.8 ) Pub Date : 2018-07-12 00:00:00 , DOI: 10.1021/acsmacrolett.8b00420 Richard Whitfield 1 , Athina Anastasaki 1 , Nghia P Truong 2 , Alexander B Cook 1 , Marta Omedes-Pujol 3 , Vanessa Loczenski Rose 3 , Tuan A H Nguyen 4 , James A Burns 3 , Sébastien Perrier 1, 2, 5 , Thomas P Davis 1, 2 , David M Haddleton 1, 2
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Double stranded RNA (dsRNA) exhibits severe degradation within 3 days in live soil, limiting its potential application in crop protection. Herein we report the efficient binding, protection, and self-release of dsRNA in live soil through the usage of a cationic polymer. Soil stability assays show that linear poly(2-(dimethylamino)ethyl acrylate) can delay the degradation of dsRNA by up to 1 week while the star shaped analogue showed an increased stabilization of dsRNA by up to 3 weeks. Thus, the architecture of the polymer can significantly affect the lifetime of dsRNA in soil. In addition, the hydrolysis and dsRNA binding and release profiles of these polymers were carefully evaluated and discussed. Importantly, hydrolysis could occur independently of environmental conditions (e.g., different pH, different temperature) showing the potential for many opportunities in agrochemicals where protection and subsequent self-release of dsRNA in live soil is required.
中文翻译：
线性和星形阳离子聚合物对土壤中 dsRNA 的高效结合、保护和自我释放
双链 RNA (dsRNA) 在活土壤中 3 天内表现出严重降解，限制了其在作物保护中的潜在应用。在此，我们报告了通过使用阳离子聚合物在活土壤中有效结合、保护和自我释放 dsRNA。土壤稳定性测定表明，线性聚 (2-(二甲基氨基)乙基丙烯酸酯) 可以将 dsRNA 的降解延迟长达 1 周，而星形类似物显示 dsRNA 的稳定性增加长达 3 周。因此，聚合物的结构可以显着影响土壤中 dsRNA 的寿命。此外，对这些聚合物的水解和 dsRNA 结合和释放曲线进行了仔细评估和讨论。重要的是，水解可以独立于环境条件（例如，不同的 pH 值、
更新日期：2018-07-12
中文翻译：
线性和星形阳离子聚合物对土壤中 dsRNA 的高效结合、保护和自我释放
双链 RNA (dsRNA) 在活土壤中 3 天内表现出严重降解，限制了其在作物保护中的潜在应用。在此，我们报告了通过使用阳离子聚合物在活土壤中有效结合、保护和自我释放 dsRNA。土壤稳定性测定表明，线性聚 (2-(二甲基氨基)乙基丙烯酸酯) 可以将 dsRNA 的降解延迟长达 1 周，而星形类似物显示 dsRNA 的稳定性增加长达 3 周。因此，聚合物的结构可以显着影响土壤中 dsRNA 的寿命。此外，对这些聚合物的水解和 dsRNA 结合和释放曲线进行了仔细评估和讨论。重要的是，水解可以独立于环境条件（例如，不同的 pH 值、
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