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Short communication: Association analysis of diacylglycerol acyltransferase (DGAT1) mutation on chromosome 14 for milk yield and composition traits, somatic cell score, and coagulation properties in Holstein bulls
Journal of Dairy Science ( IF 3.5 ) Pub Date : 2018-07-12 , DOI: 10.3168/jds.2018-14533
T. Bobbo , F. Tiezzi , M. Penasa , M. De Marchi , M. Cassandro

The aim of the present study was to determine the allele frequencies of the diacylglycerol acyltransferase (DGAT1) K232A mutation in Italian Holstein bulls and to estimate the effect of the mutation on milk yield, composition, somatic cell score, and coagulation traits (rennet coagulation time and curd firmness). For this purpose, 349 Italian Holstein bulls were genotyped for the DGAT1 mutation on chromosome 14. Association analysis was performed by regressing the number of copies for the K allele on the deregressed estimated breeding value of the individual. Breeding values were calculated using field data routinely collected in Northeast Italy. The frequencies of the AA, KA, and KK genotypes were 59.6, 32.1, and 8.3%, respectively, and the minor allele frequency (K variant) was 24.7%. The K allele was significantly associated with greater fat yield and fat, protein, and casein percentages and with reduced protein:fat ratio. The association between the DGAT1 mutation and somatic cell score was not significant, whereas a favorable association between presence of the K allele and milk coagulation properties was found. Results from the present study confirmed the effect of the diallelic DGAT1 polymorphism K232A on milk production traits and, for the first time, provided evidence that this mutation also affects milk coagulation properties in the Italian Holstein breed.



中文翻译:

简短交流:荷斯坦公牛的14号染色体上的二酰基甘油酰基转移酶(DGAT1)突变与牛奶产量和组成特征,体细胞评分和凝血特性的关联分析

本研究的目的是确定二酰基甘油的等位基因频率荷斯坦公牛的酰基转移酶(DGAT1)K232A突变,并评估该突变对牛奶产量,成分,体细胞评分和凝血特性(凝乳酶凝固时间和凝乳硬度)的影响。为此目的,对349只意大利荷斯坦公牛进行了第14号染色体DGAT1突变的基因分型,通过在个体的回归估计育种值上回归K等位基因的拷贝数来进行关联分析。繁殖值是使用在意大利东北部例行收集的田间数据计算得出的。AA,KA和KK基因型的频率分别为59.6、32.1和8.3%,次要等位基因频率(K变体)为24.7%。K等位基因与更高的脂肪产量以及脂肪,蛋白质和酪蛋白显着相关百分比和降低的蛋白质:脂肪比率。DGAT1突变与体细胞评分之间的相关性不显着,而K等位基因的存在与乳凝结特性之间存在良好的相关性。来自本研究的结果证实了拨号DGAT1多态性K232A对牛奶生产性状的影响,并且首次提供了这种突变也影响意大利荷斯坦奶牛品种的牛奶凝结特性的证据。

更新日期:2018-07-14
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