We hypothesized that plasma adipokine concentrations of early-lactation dairy cows are related to body condition score (BCS) at calving and to markers of metabolic status of the cow. As part of a larger study with 117 multiparous Holstein dairy cows, which had high BCS (BCS >4.0) or normal BCS (3.25–3.5) at calving, 22 cows were randomly selected (n = 11 per group) to be enrolled in this study. Cows were divided into 2 groups based on their BCS at calving: (1) normal BCS with BCS of 3.35 ± 0.13 (mean ± SD) and (2) high BCS cows with BCS of 4.14 ± 0.17. The 22 selected animals did not have a clinically diagnosed health problem after calving. Blood samples were taken right after calving (d 1) and before morning feeding on d 8, 15, and 21 postpartum concurrently with body condition scoring for all cows. Blood samples were analyzed for plasma adiponectin, leptin, tumor necrosis factor-α, and IL-6. The mean BCS remained highest in high-BCS cows during the first 21 d in milk. Leptin concentrations decreased progressively for all cows after calving. However, differences in BCS at calving were not related to leptin concentrations. Adiponectin, IL-6, and tumor necrosis factor-α concentrations were neither influenced by days in milk nor BCS after calving. Leptin and the leptin-to-adiponectin ratio did not show any correlation at any time point during the first 21 d in milk with plasma concentrations of nonesterified fatty acids or β-hydroxybutyrate, which are considered as markers of metabolic status. Only for IL-6 at d 8 did we find a strong correlation with metabolic status indicators. In conclusion, plasma adipokine concentrations during the first 3 wk postpartum were not related to BCS in lactating Holstein cows that were clinically healthy at calving.

我们假设血浆脂肪因子泌乳早期奶牛的浓度与产犊时的身体状况评分（BCS）和奶牛的代谢状态标记有关。作为一项较大的研究的一部分，对117头产犊的高产BCS（BCS> 4.0）或正常BCS（3.25-3.5）的荷斯坦奶牛进行了随机选择，将22头奶牛（每组n = 11）纳入该研究。学习。犊牛根据产犊时的BCS分为两组：（1）BCS为3.35±0.13（平均±SD）的正常BCS和（2）BCS为4.14±0.17的高BCS奶牛。产犊后选择的22只动物没有临床诊断的健康问题。产犊后（第1天），在产后第8、15和21天早上取食，同时对所有母牛进行身体状况评分，同时采集血样。分析血样中血浆脂联素，瘦素，肿瘤坏死因子-α和IL-6。在牛奶中的前21天中，高BCS奶牛的平均BCS保持最高。产犊后所有母牛的瘦素浓度逐渐降低。但是，产犊时BCS的差异与瘦素浓度无关。产犊后，牛奶和BCS中的脂联素，IL-6和肿瘤坏死因子-α的浓度均不受天数的影响。在最初的21天中，牛奶中的瘦素和瘦素与脂联素之比与未酯化脂肪酸或β-羟基丁酸酯的血浆浓度没有任何相关性，后者被认为是代谢状态的标志。仅对于第6天的IL-6，我们才发现其与代谢状态指标有很强的相关性。总之，产后前三周血浆中血浆脂肪因子浓度与BCS无关。哺乳期产犊的荷斯坦奶牛在临床上是健康的。