Cinnamic acid derivatives are known antifungal, antimicrobial, antioxidant, and anticancer compounds. We have developed a facile and mild methodology for the synthesis of (E)-cinnamate derivatives using a modified Steglich esterification of (E)-cinnamic acid. Using acetonitrile as the solvent, rather than the typical chlorinated solvent, and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as the coupling agent enables ester conversion in 45 min with mild heating (40–45 °C) and an average yield of 70% without need for further purification. These conditions were used to couple (E)-cinnamic acid with 1° and 2° aliphatic alcohols, benzylic and allylic alcohols, and phenols. This work demonstrates a facile and greener methodology for Steglich esterification reactions.

肉桂酸衍生物是已知的抗真菌，抗微生物，抗氧化剂和抗癌化合物。我们已经开发了用于（合成的容易且温和的方法Ë使用（的变形steglich酯化反应） -肉桂酸酯衍生物ë） -肉桂酸。使用乙腈作为溶剂，而不是典型的氯化溶剂，并使用1-乙基-3-（3-二甲基氨基丙基）碳二亚胺（EDC）作为偶联剂，可以在温和加热（40–45°C）的条件下在45分钟内完成酯转化。平均收率为70％，无需进一步纯化。这些条件用于耦合（E肉桂酸与1°和2°脂肪族醇，苄基和烯丙基醇以及酚。这项工作证明了Steglich酯化反应的简便而绿色的方法。