Abstract

A general synthesis of 3,4-dihydro-1H-furo[b]indol-1-ones, representing a furanone-fused pyrrole unit, has been developed. The dehydrohalogenative cyclization of 4-aminofuranones was achieved by reaction with Pd(OAc)₂ and DABCO in DMF. The corresponding N-protected indolones undergo alkylation at C3.

A general synthesis of 3,4-dihydro-1H-furo[b]indol-1-ones, representing a furanone-fused pyrrole unit, has been developed. The dehydrohalogenative cyclization of 4-aminofuranones was achieved by reaction with Pd(OAc)₂ and DABCO in DMF. The corresponding N-protected indolones undergo alkylation at C3.

中文翻译：

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二氢-1H-呋喃[b]吲哚-1-酮的区域选择性合成及其碳负离子反应性

摘要

已经开发了代表呋喃酮稠合的吡咯单元的3，4-二氢-1 H-呋喃[ b ]吲哚-1-酮的一般合成物。通过与Pd（OAc）₂和DABCO在DMF中反应实现了4-氨基呋喃酮的脱卤化氢环化反应。相应的N-保护的吲哚酮在C3处进行烷基化。

已经开发了代表呋喃酮稠合的吡咯单元的3，4-二氢-1 H-呋喃[ b ]吲哚-1-酮的一般合成物。通过与Pd（OAc）₂和DABCO在DMF中反应实现了4-氨基呋喃酮的脱卤化氢环化反应。相应的N-保护的吲哚酮在C3处进行烷基化。