A two-step isoindolone synthesis has been achieved by using an Ugi/oxidative vicarious nucleophilic substitution sequence starting from 3-nitrobenzoic acid and aromatic aldehydes. Loss of the amido group was observed as well as a further oxidative process towards hydroxyisoindolone derivatives after prolonged stirring open to the atmosphere.

中文翻译：

---

无金属脱酰胺 Ugi 获得异吲哚啉酮

通过使用从 3-硝基苯甲酸和芳香醛开始的 Ugi/氧化替代亲核取代序列，已经实现了两步异吲哚酮合成。观察到酰胺基团的损失以及对羟基异吲哚酮衍生物的进一步氧化过程，在向大气开放的长时间搅拌后。