The development of heterogeneous catalysts for the synthesis of pharmaceutically relevant compounds is always important for chemistry research. Here, we report a selective aerobic oxidation of aromatic and aliphatic amines to corresponding amides over a nanorod manganese oxide (NR‐MnO_x) catalyst. The kinetic studies reveal that the NR‐MnO_x catalyzed amine‐to‐amide reaction proceeds the oxidative dehydrogenation of the amines into nitriles, followed by hydrolysis of nitrile into amides. The NR−MnO_x exhibits fast kinetics and high selectivities in these steps, as well as hinders the by‐product formation. More importantly, the NR‐MnO_x catalyst is stable and reusable in the continuous recycle tests with water as a sole by‐product, exhibiting superior sustainability and significant advancement to outperform the traditional amide production route in acidic or basic media with toxic by‐products.

中文翻译：

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纳米棒氧化锰催化剂上胺中C-H键的有氧活化

开发用于合成药物相关化合物的非均相催化剂对于化学研究始终很重要。在这里，我们报告了在纳米棒锰氧化物（NR-MnO _x）催化剂上，芳香族和脂肪族胺选择性需氧氧化为相应的酰胺。动力学研究表明，NR-MnO _x催化的胺-酰胺反应将胺氧化脱氢成腈，然后将腈水解成酰胺。NR-MnO _x在这些步骤中表现出快速的动力学和高的选择性，并阻碍了副产物的形成。更重要的是，NR-MnO _x 在以水为唯一副产物的连续循环测试中，该催化剂稳定且可重复使用，具有卓越的可持续性，并取得了显着进步，性能优于在带有毒性副产物的酸性或碱性介质中的传统酰胺生产路线。