AbstractA variety of biological redox reactions are mediated by flavoenzymes due to the unique redox activity of isoalloxazine ring systems, which are found in flavin cofactors. In the field of synthetic organic chemistry, the term “flavin” is generally used for not only isoalloxazines but also related molecules including their isomers and some analogs, and those having catalytic activity are called flavin catalyst. Flavin catalysts are typically metal-free, and their catalytic activity can be readily accessed using mild terminal oxidants such as H2O2 and O2; therefore, redox reactions with these compounds have great promise as alternatives to reactions with conventional metal catalysts for the sustainable production of important chemicals. We recently became interested in using polymers for the development of flavin catalysts, especially to improve their practicality and advance the field of catalysis. Here, we summarize our recent research on such flavin–polymer collaborations including the development of facile preparation methods for flavin catalysts using polymers, readily reusable polymer-supported flavin catalysts, and flavin–peptide–polymer hybrids that can catalyze the first flavoenzyme-mimetic aerobic oxygenation reactions.Flavin catalysts are typically metal-free, and their catalytic activity can be readily accessed using mild terminal oxidants such as H2O2 and O2; therefore, redox reactions with these compounds have great promise as alternatives to reactions with conventional metal catalysts for the sustainable production of important chemicals. Herein, our recent research on flavin catalysts including the development of facile preparation methods for flavin catalysts using polymers, readily reusable polymer-supported flavin catalysts, and flavin-peptide-polymer hybrids that can catalyze the first flavoenzyme-mimetic aerobic oxygenation reactions is summarized.

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用聚合物制成的高级黄素催化剂

摘要 由于异咯嗪环系统具有独特的氧化还原活性，黄素辅助因子中存在多种生物氧化还原反应，因此黄素酶介导了多种生物氧化还原反应。在合成有机化学领域，“黄素”一词通常不仅用于异恶嗪，还用于相关分子，包括它们的异构体和一些类似物，具有催化活性的称为黄素催化剂。黄素催化剂通常不含金属，使用温和的末端氧化剂（如 H2O2 和 O2）可以很容易地获得其催化活性；因此，与这些化合物的氧化还原反应有望替代与传统金属催化剂的反应，从而实现重要化学品的可持续生产。我们最近对使用聚合物开发黄素催化剂产生了兴趣，尤其是提高它们的实用性，推进催化领域的发展。在这里，我们总结了我们最近对这种黄素-聚合物合作的研究，包括开发使用聚合物制备黄素催化剂的简便方法、易于重复使用的聚合物负载黄素催化剂，以及可以催化第一个黄素-模拟有氧的黄素-肽-聚合物杂化物。氧化反应。黄素催化剂通常不含金属，使用温和的末端氧化剂（如 H2O2 和 O2）可以很容易地获得其催化活性；因此，与这些化合物的氧化还原反应有望替代与传统金属催化剂的反应，从而实现重要化学品的可持续生产。在此处，