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Eucalyptol Inhibits Advanced Glycation End Products‐Induced Disruption of Podocyte Slit Junctions by Suppressing Rage‐Erk‐C‐Myc Signaling Pathway
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2018-08-07 , DOI: 10.1002/mnfr.201800302
Dong Yeon Kim 1 , Min-Kyung Kang 1 , Eun-Jung Lee 1 , Yun-Ho Kim 1 , Hyeongjoo Oh 1 , Young-Hee Kang 1
Affiliation  

The maintenance of interpodocyte slit diaphragm is critical in the sieving function of glomerular filtration barrier. Eucalyptol is a natural constituent in aromatic plants with antioxidant properties. This study investigates whether and how eucalyptol inhibits podocyte slit diaphragm malfunction in glucose‐exposed podocytes and diabetic mouse kidneys.

中文翻译:

桉树油通过抑制Rage-Erk-C-Myc信号通路抑制高级糖基化终产物诱导的足细胞缝隙连接的破坏

足细胞间裂隔膜的维持对于肾小球滤过屏障的筛分功能至关重要。桉树油是具有抗氧化特性的芳香植物中的天然成分。这项研究调查了桉树油是否以及如何抑制葡萄糖暴露的足细胞和糖尿病小鼠肾脏中的足细胞裂隙隔膜功能障碍。
更新日期:2018-08-07
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