Csp3–H bond functionalization of amines via tunable iminium ions: divergent synthesis of trifluoromethylated arylamines†,Chemical Communications

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Csp3–H bond functionalization of amines via tunable iminium ions: divergent synthesis of trifluoromethylated arylamines†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-07-12 00:00:00 , DOI: 10.1039/c8cc04936j
Lou Shi _{1,

2,

3,

4,

5} , Mingshan Wang _{1,

2,

3,

4,

5} , Ling Pan _{1,

2,

3,

4,

5} , Yifei Li _{1,

2,

3,

4,

5} , Qun Liu _{1,

2,

3,

4,

5}

Affiliation

A series of tunable iminium ions, generated in situ by the condensation of 4-trifluoromethyl-p-quinols with cyclic amines, can lead to the divergent synthesis of trifluoromethylated arylamines in a single step via redox-neutral isomerization. The direct α- and β-functionalization of saturated amines can be achieved regioselectively under mild conditions.

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