Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation†,Chemical Communications

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Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-07-12 00:00:00 , DOI: 10.1039/c8cc04913k
Ling-Yu Bao _{1,

2,

3,

4,

5} , Si-Jia Hao _{1,

2,

3,

4,

5} , Sai-Fei Xi _{1,

2,

3,

4,

5} , Xiaodong Yan _{1,

2,

3,

4,

5} , Hai-Xia Zhang _{1,

2,

3,

4,

5} , Rui Shen _{1,

2,

3,

4,

5} , Zhi-Guo Gu _{1,

2,

3,

4,

5}

Affiliation

Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-β (Aβ) aggregation with a high inhibition rate of 0.64–0.86. This research provides a new perspective on the design of chiral Aβ inhibitors using supramolecular metal–organic cages.

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