Quinolinone derivatives were synthesized by exchanging the ethyl group of 1-(quinolin-8-yl)propan-1-one with substituted styrenes via group-directed carbon–carbon bond cleavage. A series of substituted styrenes were reacted with 1-(quinolin-8-yl)propan-1-one for the production of various substituted 3-phenyl-1-(quinolin-8-yl)propan-1-ones in medium and good yields. The catalytic system combining [Rh(COD)Cl]₂ (5.0 mol %) with Et₃N (2.5 equiv) and 1,3-bis(diphenylphosphino)propane (10 mol %) was optimal for these transformations.

中文翻译：

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通过螯合辅助铑（I）催化的碳-碳键裂解将乙基酮直接转化为烷基酮：配体在抑制β-氢消除中起重要作用

通过基团定向的碳-碳键裂解，将1-（喹啉-8-基）丙-1-酮的乙基与取代的苯乙烯交换，从而合成喹啉酮衍生物。使一系列取代的苯乙烯与1-（喹啉-8-基）丙-1-酮反应，在中等和良好的条件下生产各种取代的3-苯基-1-（喹啉-8-基）丙-1-酮。产量。对于这些转化而言，将[Rh（COD）Cl] ₂（5.0 mol％）与Et ₃ N（2.5当量）和1,3-双（二苯基膦基）丙烷（10 mol％）结合在一起的催化体系是最佳的。