Myocardial infarction (MI) is one of the most serious health threats, resulting in huge physical and economic burdens worldwide. Wnt signaling pathways play an important role in developmental processes such as tissue patterning, cell differentiation and cell division. Appropriate regulation of the activities of Wnt signaling pathways is also important for heart development and healing in post-MI heart. Moreover, Wnt pathway inhibitors have been identified as novel antitumor drugs and applied in ongoing clinical trials. This research progress has generated increasing interests for investigating the effects of Wnt pathway inhibitors on MI healing. In this short review, we summarize the roles of Wnt signaling pathways in post-MI heart and the therapeutic effects of Wnt pathway inhibitors on MI, and discuss the underlying mechanisms of Wnt pathway inhibitors in cardiac repairing.

中文翻译：

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心肌梗死中的Wnt信号通路和Wnt通路抑制剂的治疗作用。

心肌梗塞（MI）是最严重的健康威胁之一，在全世界范围内造成巨大的身体和经济负担。Wnt信号通路在诸如组织模式，细胞分化和细胞分裂等发育过程中起着重要作用。Wnt信号通路活性的适当调节对于MI后心脏的心脏发育和愈合也很重要。此外，Wnt途径抑制剂已被鉴定为新型抗肿瘤药物，并用于正在进行的临床试验中。这项研究进展已引起越来越多的兴趣来研究Wnt通路抑制剂对MI愈合的影响。在这篇简短的评论中，我们总结了Wnt信号通路在MI后心脏中的作用以及Wnt通路抑制剂对MI的治疗作用，