Segmented flow microfluidics has attracted considerable attention owing to the excellent controllability of reaction environment. However, the accurate and stepwise addition of other reactants into the formed droplets/slugs in segmented flow is extraordinarily challenging to achieve, especially for performing particle growth and crystallization processes. Herein, we employed a segmented flow microchannel with passive picoinjection to realize the accurate addition of reactants and continuous particle manufacturing. A Venturi junction was integrated into the microchannel to control the injection volume without external power. Rapid mixing for the preparation of BaSO₄ nanoparticles with an average size of 30–40 nm, multiple injection for the growth of Au nanoparticles from 32 to 91 nm, and continuous crystallization of vaterite CaCO₃ with a high crystal purity were all successfully performed in this microchannel. The feasibility of long‐term operation and large‐scale production of particles by combining with droplet splitting was also experimentally verified. © 2018 American Institute of Chemical Engineers AIChE J, 64: 3817–3825, 2018

中文翻译：

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具有被动皮下注射的分段式微流控设备的颗粒制造中的可控性和灵活性

分段流动微流体由于其优异的反应环境可控性而引起了人们的广泛关注。然而，要以分段流动的方式将其他反应物准确地，逐步地添加到形成的液滴/段中是非常困难的，特别是对于执行颗粒生长和结晶过程而言。在这里，我们采用了分段流动微通道与被动皮下注射，以实现反应物的准确添加和连续颗粒的制造。文丘里管接头已集成到微通道中，无需外部电源即可控制进样量。快速混合以制备BaSO ₄平均直径为30–40 nm的纳米粒子，多次注入以使Au纳米粒子从32 nm增长到91 nm，以及具有高晶体纯度的球ate石CaCO ₃连续结晶均在此微通道中成功进行。通过实验验证了与液滴分裂相结合长期运行和大规模生产颗粒的可行性。©2018美国化学工程师学会AIChE J，64：3817–3825，2018