The cover feature picture shows how a computationally designed allosterically regulated esterase CaM M144H, a derivative of AlleyCatE, can recognize and specifically post‐translationally modify helical domains (highlighted in green) in calmodulin‐binding proteins with an unnatural tag providing structural and functional insight into protein–protein interactions. More information can be found in the communication by O. V. Makhlynets, I. V. Korendovych, et al. on page 1605 in Issue 15, 2018 (DOI: 10.1002/cbic.201800196).

中文翻译：

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封面文章：一种设计的酶促进选择性翻译后酰化（ChemBioChem 15/2018）

封面特征图片显示了通过计算设计的变构调节酯酶CaM M144H（AlleyCatE的衍生物）如何识别钙调蛋白结合蛋白中带有非天然标签的螺旋结构域（以绿色突出显示）并对其进行特异性翻译后修饰，从而提供了对结构和功能的了解蛋白质-蛋白质相互作用。在O. V. Makhlynets，I. V. Korendovych等人的来文中可以找到更多信息。就在第15期，2018页1605（：10.1002 / cbic.201800196 DOI）。