The gastroprotective effect of Ocimum basilicum L. (Basil) hexane extract (OBHE) in aspirin-induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were determined. Pretreatment with OBHE (100 or 200 mg kg⁻¹) or misoprostol (50 μg kg⁻¹) alleviated the aspirin-induced oxidative stress by significantly decreasing (p < 0.001) gastric ulcer index scores (57, 76 and 79%), gastric TBARS (by 49, 51 and 52%), NO (21, 28 and 29%), H₂O₂ (24, 42 and 45%), and the serum pro-inflammatory mediator TNF-α (21, 53 and 53%) and IL-6 (29, 30 and 31%), as well as by markedly increasing gastric GSH (41, 61 and 70%), GSH-Px (21, 32 and 34%), GST (33, 63 and 70%), GR (90, 99 and 112%), CAT (167, 211 and 267%) and serum PGE-2 levels (22, 135 and 200%) and IL-4 (64, 81 and 104%), respectively, compared with the aspirin-treated group. Meanwhile, OBHE and misoprostol induced a significant decrease (p < 0.001) in the freezing time (53, 56 and 64%), and the grooming time (by 25, 43 and 44%), respectively, compared to the aspirin treated group. This study provides evidence that OBHE confers anxiolytic, antioxidant and anti-inflammatory prophylactic effects on aspirin-induced gastric ulcers. GC/MS was used for the characterization of OBHE components. Based on the findings of this study, basil may be used as a nutritional supplement or therapeutic drug to protect against aspirin-induced gastric ulcers, a common problem resulting from the use of aspirin.

中文翻译：

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罗勒罗勒（Ocimum basilicum L.）（Basil）对阿司匹林诱发的小鼠胃溃疡的保护作用：对氧化应激，炎症，运动功能障碍和焦虑样行为的影响

的胃保护作用罗勒测定在阿司匹林诱发的胃溃疡的小鼠和行为改变其改善效果L.（罗勒）己烷提取物（OBHE）。预处理OBHE（100或200mg千克^-1）或米索前列醇（50微克千克^-1）通过显著降低（缓解了阿司匹林诱导的氧化应激p <0.001）胃溃疡指数评分（57，76和79％），胃TBARS（分别降低49％，51％和52％），NO（21％，28％和29％），H ₂ O ₂（24％，42％和45％），以及血清促炎性介质TNF-α（21％，53％和53％）和IL-6（29％，30％和31％），以及显着增加的胃GSH（41 ，61和70％），GSH-Px（21、32和34％），GST（33、63和70％），GR（90、99和112％），CAT（167、211和267％）和血清与阿司匹林治疗组相比，PGE-2（分别为22％，135％和200％）和IL-4（分别为64％，81％和104％）水平。同时，OBHE和米索前列醇诱导显着降低（p与阿司匹林治疗组相比，冷冻时间（分别为53％，56％和64％）<0.001，修饰时间（分别为25％，43％和44％）。这项研究提供的证据表明，OBHE对阿司匹林诱发的胃溃疡具有抗焦虑，抗氧化和抗炎的预防作用。GC / MS用于表征OBHE组分。根据这项研究的结果，罗勒可用作营养补充剂或治疗药物，以预防由阿司匹林引起的胃溃疡，这是使用阿司匹林引起的常见问题。