Abstract

A three-step procedure for the synthesis of 1H-benzo[b]xanthene-6,11,12-trione derivatives is described. The procedure involves the halogenation of 12-(3-hydroxy-1,4-naphthoquinon-2-yl)-6H-benzo[b]xanthene-6,11-(12H)-diones, followed by treatment with water under aeration. In this manner, bikaverin, a cytotoxic metabolite isolated from several species of the fungal genera Gibberella, Fusarium, and Mycogone, was synthesised.

A three-step procedure for the synthesis of 1H-benzo[b]xanthene-6,11,12-trione derivatives is described. The procedure involves the halogenation of 12-(3-hydroxy-1,4-naphthoquinon-2-yl)-6H-benzo[b]xanthene-6,11-(12H)-diones, followed by treatment with water under aeration. In this manner, bikaverin, a cytotoxic metabolite isolated from several species of the fungal genera Gibberella, Fusarium, and Mycogone, was synthesised.

中文翻译：

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苯并[b]黄嘌呤-6,11,12-三酮的简单路线：比卡维林的合成

摘要

描述了合成1 H-苯并[ b ]氧杂蒽-6,11,12-三酮衍生物的三步程序。该程序包括将12-（3-羟基-1,4-萘醌-2-基）-6 H-苯并[ b ]]吨-6,11-（12 H）-二酮卤化，然后在减压下用水处理通风。以这种方式，合成了比卡韦林，这是一种从真菌属赤霉菌，镰刀菌属和霉菌酮的几种物种中分离出来的细胞毒性代谢产物。

描述了合成1 H-苯并[ b ]氧杂蒽-6,11,12-三酮衍生物的三步程序。该程序包括将12-（3-羟基-1,4-萘醌-2-基）-6 H-苯并[ b ]]吨-6,11-（12 H）-二酮卤化，然后在减压下用水处理通风。以这种方式，合成了比卡韦林，这是一种从真菌属赤霉菌，镰刀菌属和霉菌酮的几种物种中分离出来的细胞毒性代谢产物。