A numerical correction method is proposed for the moment analysis of some properties of chromatographic columns, even when the profiles of their elution peaks exhibit some asymmetry. Information on the retention equilibrium and the mass transfer kinetics of a C₁₈-silica gel packing material is derived by the moment analysis from the experimental data obtained under three different sets of conditions: (1) the tailing peaks eluted from the column used; they are not corrected by the numerical method; (2) the same peaks are corrected by the numerical method, which provides the information on the column radial heterogeneity and on the efficiency at its center; and (3) symmetrical peaks having nearly Gaussian profiles eluted from another column packed with the same material; these peaks are not corrected by the numerical method. The analytical results obtained under the three different conditions are compared. The results demonstrate that the numerical correction method allows the determination of the information on the chromatographic behavior of columns from asymmetrical peak profiles, i.e., column efficiency at radial center, order of the polynomial functions for representing the radial distributions of mobile phase flow velocity and column efficiency, ratio of the flow velocity near the wall to that at the column center, and ratio of the column efficiency near the wall to that at the column center.

提出了一种数值校正方法来对色谱柱的某些特性进行矩分析，即使其洗脱峰的轮廓表现出一定的不对称性也是如此。有关C ₁₈的保留平衡和传质动力学的信息-硅胶填充材料是通过力矩分析从在三组不同条件下获得的实验数据得出的：（1）从所用色谱柱上洗脱下来的拖尾峰；它们没有通过数值方法进行校正；（2）通过数值方法校正相同的峰，从而提供有关色谱柱径向异质性及其中心效率的信息；（3）从另一根装有相同材料的色谱柱上洗脱出来的具有几乎高斯分布的对称峰；这些峰值未通过数值方法进行校正。比较了在三种不同条件下获得的分析结果。结果表明，数值校正方法可以从不对称峰轮廓确定色谱柱色谱行为的信息，即