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Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them.
Mucosal Immunology ( IF 8 ) Pub Date : 2019-Jan-01 , DOI: 10.1038/s41385-018-0053-0
Matthew T Sorbara 1 , Eric G Pamer 1, 2
Affiliation  

The communities of bacteria that reside in the intestinal tract are in constant competition within this dynamic and densely colonized environment. At homeostasis, the equilibrium that exists between these species and strains is shaped by their metabolism and also by pathways of active antagonism, which drive competition with related and unrelated strains. Importantly, these normal activities contribute to colonization resistance by the healthy microbiota, which includes the ability to prevent the expansion of potential pathogens. Disruption of the microbiota, resulting from, for example, inflammation or antibiotic use, can reduce colonization resistance. Pathogens that engraft following disruption of the microbiota are often adapted to expand into newly created niches and compete in an altered gut environment. In this review, we examine both the interbacterial mechanisms of colonization resistance and the strategies of pathogenic strains to exploit gaps in colonization resistance.

中文翻译:

定植抗性的细菌间机制和病原体用来克服它们的策略。

居住在肠道中的细菌群落在这个动态和密集繁殖的环境中不断竞争。在体内平衡中,这些物种和菌株之间存在的平衡是由它们的新陈代谢和主动拮抗途径决定的,这些途径推动了与相关和无关菌株的竞争。重要的是,这些正常活动有助于健康微生物群的定植抵抗,包括防止潜在病原体扩散的能力。微生物群的破坏,例如,由炎症或抗生素使用引起的,可以降低定植抗性。在微生物群破坏后植入的病原体通常会适应扩展到新创建的生态位并在改变的肠道环境中竞争。在这篇评论中,
更新日期:2018-07-10
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