A continuous flow process for the reductive deoxygenation of 3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile to 3-(4-chlorobutyl)-1H-indole-5-carbonitrile was developed using a continuous stirred tank reactor (CSTR) setup. The opportunity for process optimization as well as scale-up feasibility was investigated at a laboratory scale. Advantages of a continuous process such as increased product yield, minimized impurity formation, enhanced safety, and increased overall purity of the isolated material thereby avoiding a purification step were demonstrated. Both sodium borohydride and a borane·THF complex were explored as reducing agents in conjunction with iron trichloride which produced high purity 3-(4-chlorobutyl)-1H-indole-5-carbonitrile not requiring further purification in higher yield than the standard batch process.

中文翻译：

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伏拉唑酮合成中ω-氯酮还原脱氧的连续流工艺

为3-（4-氯丁酰基）的还原脱氧阿连续流动过程-1 ħ -吲哚-5-甲腈向3-（4-氯丁基）-1 ħ -吲哚-5-甲腈使用连续搅拌釜反应器开发（CSTR）设置。在实验室规模上研究了工艺优化的机会以及扩大规模的可行性。证明了连续过程的优点，例如增加了产品的收率，减少了杂质的形成，提高了安全性以及提高了所分离材料的总纯度，从而避免了纯化步骤。硼氢化钠和硼烷·THF配合物均与三氯化铁一起用作还原剂，三氯化铁可产生高纯度的3-（4-氯丁基）-1 H-吲哚-5-腈不需要比标准间歇方法更高的收率进行进一步纯化。