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Antibody–Bactericidal Macrocyclic Peptide Conjugates To Target Gram‐Negative Bacteria
ChemBioChem ( IF 3.2 ) Pub Date : 2018-09-14 , DOI: 10.1002/cbic.201800295
Fayçal Touti 1 , Guillaume Lautrette 1 , Kenneth D. Johnson 2 , James C. Delaney 2 , Andrew Wollacott 2 , Hamid Tissire 2 , Karthik Viswanathan 2 , Zachary Shriver 2 , Surin K. Mong 1 , Alexander J. Mijalis 1 , Obadiah J. Plante 2 , Bradley L. Pentelute 1
Affiliation  

The best of both worlds: To discover novel antibiotics with improved properties, macrocyclic antimicrobial peptides are conjugated to an engineered monoclonal antibody targeted against E. coli. This approach affords antibody–bactericide conjugates with potent killing of E. coli and minimized hemolytic activity.
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中文翻译:

抗体杀菌大环肽结合至革兰氏阴性菌

两全其美:为了发现具有改进特性的新型抗生素,将大环抗菌肽与针对大肠杆菌的工程化单克隆抗体缀合。这种方法提供了可有效杀死大肠杆菌并最小化溶血活性的抗体-杀菌剂结合物。
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更新日期:2018-09-14
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