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Purkinje Cell Representations of Behavior: Diary of a Busy Neuron
The Neuroscientist ( IF 5.6 ) Pub Date : 2018-07-09 , DOI: 10.1177/1073858418785628
Laurentiu S. Popa 1 , Martha L. Streng 1 , Timothy J. Ebner 1
Affiliation  

The cerebellum is essential for the production of smooth, continuous movements. More recently, the cerebellum’s role in non-motor functions has emerged including cognitive processes and executive control. With its remarkably stereotypic circuitry, it is widely held that the cerebellum provides a uniform computation (Ito 2008; Ramnani 2006; Schmahmann 2010; Thach 2007). One of the main challenges in cerebellar neurobiology is to define the uniform computation and determine how it is used across all functional domains. Solving this challenge requires understanding how information is encoded and processed during behaviors throughout the cerebellar circuitry. At present, most of the available information centers on Purkinje cell encoding of motor behavior. As the only output neurons of the cerebellar cortex, Purkinje cells are a key node in the network and, therefore, are integral to understanding cerebellar function. This review focuses on the signals represented in the discharge of Purkinje cells and what those signals tell us about cerebellar function.

中文翻译:

行为的浦肯野细胞表示:繁忙的神经元的日记

小脑对于产生平稳,连续的动作至关重要。最近,小脑在非运动功能中的作用已经出现,包括认知过程和执行控制。凭借其显着的定型电路,人们普遍认为小脑提供了统一的计算(Ito 2008; Ramnani 2006; Schmahmann 2010; Thach 2007)。小脑神经生物学的主要挑战之一是定义统一的计算并确定如何在所有功能域中使用它。解决这一挑战需要了解整个小脑电路在行为过程中如何对信息进行编码和处理。目前,大多数可用信息都集中在运动行为的Purkinje细胞编码上。作为小脑皮层的唯一输出神经元,浦肯野细胞是网络中的关键节点,因此对于理解小脑功能是必不可少的。这篇综述着重于浦肯野细胞放电中所代表的信号以及这些信号告诉我们的小脑功能。
更新日期:2018-07-09
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