We present the synthesis of polymeric nanoparticles of targeted morphology in a continuous process via visible light-mediated aqueous RAFT polymerization-induced self-assembly (PISA). A trithiocarbonate-derived poly(ethylene glycol) (PEG) macroRAFT was activated in the presence of hydroxypropyl methacrylate (HPMA) at 37 °C under blue light irradiation (460 nm), leading to the formation of PEG-b-P(HPMA) nanoparticles. The method is attractive in its simplicity—spheres, worms, and vesicles can easily be obtained in a continuous fashion with higher control in comparison to conventional batch procedures. This allows for more accurate production of particle morphologies and scalable synthesis of these nano-objects. The versatility of this process was demonstrated by the in situ encapsulation of an active compound.

中文翻译：

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使用连续流反应器的可见光介导聚合诱导的自组装

我们介绍了通过可见光介导的水性RAFT聚合诱导的自组装（PISA）在连续过程中的目标形态的聚合物纳米粒子的合成。在甲基丙烯酸羟丙酯（HPMA）存在下，在37°C蓝光照射下（460 nm），激活了源自三硫代碳酸酯的聚乙二醇（PEG）macroRAFT，导致形成PEG- b -P（HPMA）纳米粒子。该方法的简单性很吸引人-与常规的批处理程序相比，球，蠕虫和囊泡可以轻松地以连续的方式获得，并且具有更高的控制力。这样可以更精确地生成颗粒形态，并可以扩展地合成这些纳米物体。此过程的多功能性由原位证明 活性化合物的包封。