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Progress in Applications of Prussian Blue Nanoparticles in Biomedicine
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-07-04 , DOI: 10.1002/adhm.201800347
Zhiguo Qin 1 , Yan Li 1 , Ning Gu 1
Affiliation  

Prussian blue nanoparticles (PBNPs) with favorable biocompatibility and unique properties have captured the attention of extensive biomedical researchers. A great progress is made in the application of PBNPs as therapy and diagnostics agents in biomedicine. This review begins with the recent synthetic strategies of PBNPs and the regulatory approaches for their size, shape, and uniformity. Then, according to the different properties of PBNPs, their application in biomedicine is summarized in detail. With modifiable features, PBNPs can be used as drug carriers to improve the therapeutic efficacy. Moreover, the exchangeable protons and adsorbability enable PBNPs to decontaminate the radioactive ions from the body. For biomedical imaging, photoacoustic and magnetic resonance imaging based on PBNPs are summarized, as well as the strategies to improve the diagnostic effectiveness. The applications related to the photothermal effects and nanoenzyme activities of PBNPs are described. The challenges and critical factors for the clinical translation of PBNPs as multifunctional theranostic agents are also discussed. Finally, the future prospects for the application of PBNPs are considered. The aim of this review is to provide a better understanding and key consideration for rational design of this increasingly important new paradigm of PBNPs as theranostics.

中文翻译:

普鲁士蓝纳米粒子在生物医学中的应用进展

具有良好的生物相容性和独特性能的普鲁士蓝纳米颗粒(PBNP)引起了广泛的生物医学研究人员的关注。PBNPs在生物医学中作为治疗剂和诊断剂的应用取得了巨大的进步。这篇综述从PBNPs的最新合成策略及其大小,形状和均匀性的调控方法开始。然后,根据PBNPs的不同性质,详细总结了其在生物医学中的应用。PBNP具有可修改的功能,可以用作药物载体以改善治疗效果。此外,可交换的质子和吸附性使PBNP能够净化人体中的放射性离子。对于生物医学成像,总结了基于PBNP的光声和磁共振成像,以及提高诊断效率的策略。描述了与PBNPs的光热效应和纳米酶活性有关的应用。还讨论了PBNPs作为多功能治疗剂的临床翻译所面临的挑战和关键因素。最后,考虑了PBNP应用的未来前景。这篇综述的目的是为合理设计这种越来越重要的PBNP作为治疗诊断学的新范式提供更好的理解和关键考虑。考虑了PBNP应用的未来前景。这篇综述的目的是为合理设计这种越来越重要的PBNP作为治疗诊断学的新范式提供更好的理解和关键考虑。考虑了PBNP应用的未来前景。这篇综述的目的是为合理设计这种越来越重要的PBNP作为治疗诊断学的新范式提供更好的理解和关键考虑。
更新日期:2018-07-04
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