Existing analytical techniques used for the determination of cannabinoids in Cannabis sativa L. (Cannabis) plants mostly rely on chromatography-based methods. As a rapid alternative for the direct analysis of them, thermal desorption (TD)-ion mobility spectrometry (IMS) was used for obtaining spectral fingerprints of single cannabinoids from Cannabis plant extracts and from plant residues on hands after their manipulation. The ionization source was ⁶³Ni, with automatic switchable polarity. Although in both ionization modes there were signals in the TD-IMS spectra of the plant extracts and residues that could be assigned to concrete cannabinoids and chemotypes, most of them could not be clearly distinguished. Alternatively, the global spectral data of the plant extracts and residues were pre-processed and then, using principal component analysis (PCA)-linear discriminant analysis (LDA), grouped in function of their chemotype in a more feasible way. Using this approach, the possibility of false positive responses was also studied analyzing other non-Cannabis plants and tobacco, which were clustered in a different group to those of Cannabis. Therefore, TD-IMS, as analytical tool, and PCA-LDA, as a strategy for data reduction and pattern recognition, can be applied for on-site chemotaxonomic discrimination of Cannabis varieties and detection of illegal marijuana since the IMS equipment is portable and the analysis time is highly short.

现有用于大麻素在确定的分析技术大麻L.（大麻）植物大多依赖于基于色谱法的方法。作为直接分析它们的快速替代方法，热解吸（TD）离子迁移谱（IMS）用于从大麻植物提取物中和操作后的手中植物残留物中获得单个大麻素的光谱指纹。电离源为⁶³镍，具有自动切换的极性。尽管在两种电离模式下，植物提取物和残留物的TD-IMS光谱中都有信号可以分配给具体的大麻素和化学型，但大多数信号并不能清晰地区分。或者，对植物提取物和残留物的全局光谱数据进行预处理，然后使用主成分分析（PCA）-线性判别分析（LDA），以更可行的方式对它们的化学型进行分组。使用这种方法，也进行了研究的假阳性反应的可能性分析其他非大麻植物和烟草，这是集中在不同的组那些大麻。因此，TD-IMS作为分析工具，而PCA-LDA作为数据减少和模式识别的策略，由于IMS设备是便携式的，因此可以用于大麻品种的现场化学分类判别和非法大麻的检测。分析时间非常短。