Mixed micellization of an amphiphilic drug amitriptyline hydrochloride and surface active ionic liquids: interfacial and micellization studies,Chemical Physics Letters

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Mixed micellization of an amphiphilic drug amitriptyline hydrochloride and surface active ionic liquids: interfacial and micellization studies
Chemical Physics Letters ( IF 2.8 ) Pub Date : 2018-07-05 , DOI: 10.1016/j.cplett.2018.07.001
Amalendu Pal , Alka Yadav

The mixed micellization behavior of surface active ionic liquids (SAILs), 1-dodecyl-3-methylimidazolium chloride, [C₁₂mim][Cl], and 1-tetradecyl-3-methylimidazolium chloride, [C₁₄mim][Cl] with an amphiphilic drug amitriptyline hydrochloride (AMT) have been studied using surface tension and conductance. Interfacial parameters obtained from surface tension were beneficial in deciphering the phenomenon taking place at the interface. Critical micelle concentration (cmc), and various thermodynamic parameters were achieved from conductance. The negative values of $Δ G_{mic .}^{\circ}$ $<math><mrow is="true"><mi mathvariant="normal" is="true">Δ</mi><msubsup is="true"><mi is="true">G</mi><mrow is="true"><mi mathvariant="italic" is="true">mic</mi><mo is="true">.</mo></mrow><mo is="true">∘</mo></msubsup></mrow></math>$ and $Δ G_{ad .}^{\circ}$ $<math><mrow is="true"><mi mathvariant="normal" is="true">Δ</mi><msubsup is="true"><mi is="true">G</mi><mrow is="true"><mi mathvariant="italic" is="true">ad</mi><mo is="true">.</mo></mrow><mo is="true">∘</mo></msubsup></mrow></math>$ indicate the feasibility of the mixed micellization process. Rubingh and Motomura introduced theoretical model for micellar interaction parameter ( $β^{m}$ $<math><msup is="true"><mi is="true">β</mi><mi is="true">m</mi></msup></math>$ ) have been examined to investigate the interactions between AMT and the SAILs.

中文翻译：

两亲药物阿米替林盐酸盐和表面活性离子液体的混合胶束化：界面和胶束化研究

表面活性离子液体（SAIL），1-十二烷基-3-甲基咪唑氯化物[C ₁₂ mim] [Cl]和1-十四烷基-3-甲基咪唑氯化物[C ₁₄ mim] [Cl]的混合胶束化行为与使用表面张力和电导率研究了两亲药物盐酸阿米替林（AMT）。从表面张力获得的界面参数有利于破译在界面处发生的现象。临界胶束浓度（cmc）和各种热力学参数可从电导中获得。的负值 $Δ G_{mic .}^{\circ}$ $<math><mrow is="true"><mi mathvariant="normal" is="true">Δ</mi><msubsup is="true"><mi is="true">G</mi><mrow is="true"><mi mathvariant="italic" is="true">mic</mi><mo is="true">.</mo></mrow><mo is="true">∘</mo></msubsup></mrow></math>$ 和 $Δ G_{ad .}^{\circ}$ $<math><mrow is="true"><mi mathvariant="normal" is="true">Δ</mi><msubsup is="true"><mi is="true">G</mi><mrow is="true"><mi mathvariant="italic" is="true">ad</mi><mo is="true">.</mo></mrow><mo is="true">∘</mo></msubsup></mrow></math>$ 表明混合胶束化过程的可行性。鲁宾（Rubingh）和本村（Motomura）引入了胶束相互作用参数的理论模型（ $β^{m}$ $<math><msup is="true"><mi is="true">β</mi><mi is="true">m</mi></msup></math>$ ）已进行了调查，以调查AMT与SAIL之间的相互作用。

更新日期：2018-07-08

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