A novel Al¹⁸F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.

中文翻译：

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新型催产素受体示踪剂的高产 18F 放射合成，一种用于体内鼻对脑摄取催产素的探针†

一种用于催产素受体 PET 成像的新型 Al ¹⁸ F 标记肽示踪剂已通过高放射化学产率方法获得。与催产素相比，这种示踪剂显示出相当的亲和力和更高的选择性和稳定性，并被用于证明鼻内给药后鼻对脑的直接摄取，这是一种常见但有争议的催产素疗法的递送途径。