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Environmental phenols and parabens in adipose tissue from hospitalized adults in Southern Spain
Environment International ( IF 11.8 ) Pub Date : 2018-07-04 , DOI: 10.1016/j.envint.2018.05.052
F. Artacho-Cordón , M.F. Fernández , H. Frederiksen , L.M. Iribarne-Durán , I. Jiménez-Díaz , F. Vela-Soria , A.M. Andersson , P. Martin-Olmedo , F.M. Peinado , N. Olea , J.P. Arrebola

Urinary concentrations of non-persistent environmental pollutants (npEPs) are widely assessed in biomonitoring studies under the assumption that they are metabolised and eliminated in urine. However, some of these chemicals are moderately lipophilic, and their presence in other biological matrices should also be evaluated to estimate mid/long-term exposure to npEPs and its impact on human health. The present study aims to explore concentrations and potential determinants of npEPs in adipose tissue from a hospital-based adult cohort (GraMo cohort, Southern Spain).

Concentrations of bisphenol-A (BPA), benzophenone-3 (BP-3), triclosan (TCS), three chlorophenols (2,4-DCP, 2,5-DCP and 2,4,5-TCP) and two phenylphenols (2-PP and 4-PP), triclocarban (TCCB) and parabens [methyl- (MeP), ethyl- (EtP), propyl- (n-PrP and i-PrP), butyl- (n-BuP and i-BuP) and benzyl-paraben (BzP)] were analysed in adipose tissue samples from a subcohort of 144 participants. Spearman correlation tests were performed, followed by stepwise multivariable linear regression analyses to assess determinants of the exposure.

Detection frequencies and median concentrations were: BPA (86.8%, 0.54 ng/g tissue), BP-3 (79.2%, 0.60 ng/g tissue), TCS (45.8%, <LOD), 2-PP (18.8%, <LOD), MeP (100.0%, 0.40 ng/g tissue), EtP (20.1%, <LOD) and n-PrP (54.2%, 0.06 ng/g tissue). The remaining npEPs were detected in <10% of the samples. BPA, MeP, EtP and n-PrP levels were significantly and positively correlated, while BP-3 showed a positive correlation with TCS and 2-PP. Older participants showed higher concentrations of TCS and MeP, while BMI was inversely associated with most of the analysed compounds and perceived recent weight loss was inversely associated with 2-PP. Female participants and residents of rural areas had increased BP-3 concentrations. npEP concentrations were positively associated with the consumption of fatty food but negatively associated with the consumption of vegetables and fruit.

This study reveals the widespread presence of numerous npEPs in adipose tissue from adults in southern Spain, suggesting a generalized distribution of these environmental compounds in fatty tissues. In these adults, many of the determinants of npEP concentrations in adipose tissue were similar to those of more lipophilic and persistent compounds.



中文翻译:

西班牙南部住院成年人脂肪组织中的环境酚和对羟基苯甲酸酯

在生物监测研究中,假设非持久性环境污染物(npEPs)在尿中被代谢并消除,因此对它们的尿液浓度进行了广泛的评估。但是,其中一些化学药品具有中等亲脂性,还应该评估它们在其他生物基质中的存在,以估计npEPs的中/长期暴露量及其对人体健康的影响。本研究旨在探讨以医院为基础的成年队列(GraMo队列,西班牙南部)的脂肪组织中npEPs的浓度和潜在决定因素。

双酚A(BPA),二苯甲酮3(BP-3),三氯生(TCS),三种氯酚(2,4-DCP,2,5-DCP和2,4,5-TCP)和两种苯基酚( 2-PP和4-PP),三氯卡班(TCCB)和对羟基苯甲酸酯[甲基-(MeP),乙基-(EtP),丙基-(n-PrP和i-PrP),丁基-(n-BuP和i-BuP )和对羟基苯甲酸苄酯(BzP)]在来自144个参与者的亚人群的脂肪组织样品中进行了分析。进行Spearman相关检验,然后进行逐步多变量线性回归分析以评估暴露的决定因素。

检测频率和中位数浓度为:BPA(86.8%,0.54 ng / g组织),BP-3(79.2%,0.60 ng / g组织),TCS(45.8%,<LOD),2-PP(18.8%,< LOD),MeP(100.0%,0.40 ng / g组织),EtP(20.1%,<LOD)和n-PrP(54.2%,0.06 ng / g组织)。在<10%的样品中检测到了其余的npEP。BPA,MeP,EtP和n-PrP水平显着正相关,而BP-3与TCS和2-PP正相关。年龄较大的参与者表现出较高的TCS和MeP浓度,而BMI与大多数分析化合物成反比,而近期体重减轻与2-PP成反比。女性参与者和农村地区居民的BP-3浓度升高。

这项研究揭示了西班牙南部成年人脂肪组织中大量npEP的广泛存在,表明这些环境化合物在脂肪组织中的普遍分布。在这些成年人中,脂肪组织中npEP浓度的许多决定因素与亲脂性和持久性化合物的决定因素相似。

更新日期:2018-07-12
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