Dienogest is a synthetic oral progestogen with unique pharmacological properties that is used orally in the treatment of endometrosis. The first time, the detailed electrochemical mechanism of dienogest is investigated in different aqueous mediums. Different progestins were used to understand completely oxidation mechanism. The electrochemical oxidation of dienogest was investigated systematically by cyclic voltammetry, differential pulse voltammetry, and square wave voltammetry. A simple adsorptive stripping square wave voltammetry method has been developed for the fully validated direct determination of dienogest in Visanne Tablets for the first time. Nano based sensor was fabricated with reduced graphene oxide, gold and carboxylic acid functionalized multi‐walled carbon nanotube materials, and were used on glassy carbon electrode that performed sensitive and validated analysis of dienogest by adsorptive stripping square wave voltammetry. Validation parameters were investigated in detail. The results yielded good precision, accuracy and reproducibility. Calibration range was found as 2.00×10⁻⁷ M to 6.00×10⁻⁶ M, with LOD and LOQ values as 1.88×10⁻⁸ M and 6.27×10⁻⁸ M, respectively. In the future, the developed sensor can be applied in different media such as environment, soil and water for the detection of some progestins or hormones by researchers.

中文翻译：

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水性介质中口服孕激素的机理的电化学方法及其通过碳金属基复合传感器的完全验证检测

Dienogest是一种具有独特药理特性的合成口服孕激素，可口服用于治疗子宫内膜异位症。第一次，在不同的水介质中研究了二烯诺孕酮的详细电化学机理。使用不同的孕激素来完全了解氧化机理。通过循环伏安法，差分脉冲伏安法和方波伏安法系统地研究了二烯诺孕酮的电化学氧化。已开发出一种简单的吸附剥离方波伏安法，首次用于完全验证的直接测定Visanne片剂中的二烯诺孕酮。基于纳米的传感器是用还原的氧化石墨烯，金和羧酸官能化的多壁碳纳米管材料制成的，并用在玻碳电极上，通过吸附溶出方波伏安法进行了敏感的和经过验证的二烯诺孕酮分析。验证参数进行了详细研究。结果产生了良好的精度，准确性和可重复性。校准范围为2.00×10^-7  M至6.00×10 ^-6  M，LOD和LOQ值分别为1.88×10 ^-8  M和6.27×10 ^-8M  。将来，开发的传感器可以应用于环境，土壤和水等不同介质中，以供研究人员检测某些孕激素或激素。