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Employing proteomics to understand the effects of nutritional intervention in cancer treatment
Analytical and Bioanalytical Chemistry ( IF 4.3 ) Pub Date : 2018-07-04 , DOI: 10.1007/s00216-018-1219-z
Monica M Schroll 1, 2 , Amanda B Hummon 3
Affiliation  

Lifestyle optimizations are implementable changes that can have an impact on health and disease. Nutrition is a lifestyle optimization that has been shown to be of great importance in cancer initiation, progression, and metastasis. Dozens of clinical trials are currently in progress that focus on the nutritional modifications that cancer patients can make prior to and during medical care that increase the efficacy of treatment. In this review, we discuss various nutritional inventions for cancer patients and the analytical approaches to characterize the downstream molecular effects. We first begin by briefly explaining the many different forms of nutritional intervention currently being used in cancer treatment as well as their motivating biology. The forms of nutrient modulation described in this review include calorie restriction, the different practices of fasting, and carbohydrate restriction. The review then shifts to explain how proteomics is used to determine biomarkers of cancer and how it can be utilized in the future to determine the metabolic phenotype of a tumor, and inform physicians if nutritional intervention should be recommended for a cancer patient. Nutrigenomics aims to understand the relationship of nutrients and gene expression and can be used to understand the downstream molecular effects of nutrition restriction, partially through proteomic analysis. Proteomics is just beginning to be used as cancer diagnostic and predictive tools. However, these approaches have not been used to their full potential to understand nutritional intervention in cancer.

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中文翻译:

利用蛋白质组学了解营养干预在癌症治疗中的作用

生活方式优化是可以对健康和疾病产生影响的可实施的改变。营养是一种生活方式的优化,已被证明在癌症的发生、进展和转移中非常重要。目前正在进行数十项临床试验,重点关注癌症患者在医疗护理之前和期间可以进行的营养调整,以提高治疗效果。在这篇综述中,我们讨论了针对癌症患者的各种营养发明以及表征下游分子效应的分析方法。我们首先简要解释目前在癌症治疗中使用的许多不同形式的营养干预及其激励生物学。本综述中描述的营养调节形式包括热量限制、禁食和限制碳水化合物的不同做法。然后,审查转向解释如何使用蛋白质组学来确定癌症的生物标志物,以及将来如何利用它来确定肿瘤的代谢表型,并告知医生是否应该为癌症患者推荐营养干预。营养基因组学旨在了解营养物质和基因表达的关系,并可用于了解营养限制的下游分子效应,部分通过蛋白质组学分析。蛋白质组学刚刚开始被用作癌症诊断和预测工具。然而,这些方法尚未充分发挥其了解癌症营养干预的潜力。然后,审查转向解释如何使用蛋白质组学来确定癌症的生物标志物,以及将来如何利用它来确定肿瘤的代谢表型,并告知医生是否应该为癌症患者推荐营养干预。营养基因组学旨在了解营养物质和基因表达的关系,并可用于了解营养限制的下游分子效应,部分通过蛋白质组学分析。蛋白质组学刚刚开始被用作癌症诊断和预测工具。然而,这些方法尚未充分发挥其了解癌症营养干预的潜力。然后,审查转向解释如何使用蛋白质组学来确定癌症的生物标志物,以及将来如何利用它来确定肿瘤的代谢表型,并告知医生是否应该为癌症患者推荐营养干预。营养基因组学旨在了解营养物质和基因表达的关系,并可用于了解营养限制的下游分子效应,部分通过蛋白质组学分析。蛋白质组学刚刚开始被用作癌症诊断和预测工具。然而,这些方法尚未充分发挥其了解癌症营养干预的潜力。并告知医生是否应该为癌症患者推荐营养干预。营养基因组学旨在了解营养物质和基因表达的关系,并可用于了解营养限制的下游分子效应,部分通过蛋白质组学分析。蛋白质组学刚刚开始被用作癌症诊断和预测工具。然而,这些方法尚未充分发挥其了解癌症营养干预的潜力。并告知医生是否应该为癌症患者推荐营养干预。营养基因组学旨在了解营养物质和基因表达的关系,并可用于了解营养限制的下游分子效应,部分通过蛋白质组学分析。蛋白质组学刚刚开始被用作癌症诊断和预测工具。然而,这些方法尚未充分发挥其了解癌症营养干预的潜力。

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更新日期:2018-07-04
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