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Dimethyl carbonate as a non-innocent benign solvent for the multistep continuous flow synthesis of amino alcohols†
Reaction Chemistry & Engineering ( IF 3.9 ) Pub Date : 2018-07-04 00:00:00 , DOI: 10.1039/c8re00097b
Raul Porcar 1, 2, 3, 4 , Pedro Lozano 5, 6, 7, 8, 9 , Maria Isabel Burguete 1, 2, 3, 4 , Eduardo Garcia-Verdugo 1, 2, 3, 4 , Santiago V. Luis 1, 2, 3, 4
Affiliation  

An efficient methodology for the production and resolution of amino alcohols with a low environmental impact has been developed. The system is based on the assembly of three different well compartmentalised catalytic modules allowing the combination of catalytic and biocatalytic elements. Dimethyl carbonate is used as a green but non-innocent solvent, playing a dual role as the solvent and reagent for two out of the three synthetic steps considered. The use of polymer-supported ionic liquids (SILLPS) is key for the development of some of the catalytic systems optimised.

中文翻译:

碳酸二甲酯作为氨基醇的多步连续流合成的一种非无害的良性溶剂

已经开发出了一种对环境影响较小的生产和拆分氨基醇的有效方法。该系统基于三个不同的间隔良好的催化模块的组装,允许催化元素和生物催化元素的组合。碳酸二甲酯用作绿色但无害的溶剂,在所考虑的三个合成步骤中的两个中,起着溶剂和试剂的双重作用。使用聚合物负载的离子液体(SILLPS)是开发某些优化的催化系统的关键。
更新日期:2018-07-04
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