We have identified the bacterial signal recognition particle (SRP) as a novel antibacterial target. As a proof of principle, we used an antisense peptide nucleic acid to target a key SRP RNA. The PNA molecules showed efficient inhibition of SRP function and bacterial cell growth, thereby validating our hypothesis.

中文翻译：

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肽核酸介导的细菌信号识别颗粒的抑制作用†

我们已将细菌信号识别颗粒（SRP）确定为新型抗菌靶标。作为原理的证明，我们使用了反义肽核酸来靶向关键的SRP RNA。PNA分子显示出有效抑制SRP功能和细菌细胞生长，从而验证了我们的假设。