A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl₂ and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl₂/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr²⁺ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability. Implantation of the BP-SrCl₂/PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr²⁺ at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time.

近红外（NIR）光触发的药物递送平台是通过将所产生的SrCl ₂和BP纳米片（BPS）到聚（乳酸-共-glycolic乙酸）（PLGA），用于骨再生。所制造的BP-SrCl ₂ / PLGA微球由于BP而显示出有效的NIR吸收和光热效应。研究了通过破坏PLGA壳而通过NIR触发的Sr ²⁺的释放行为，并且微球表现出优异的细胞活力和生物降解性。将BP-SrCl ₂ / PLGA微球植入大鼠股骨缺损显示出良好的组织相容性和在NIR光照射下具有出色的骨再生能力。我们的研究表明Sr ^2+的局部释放 在NIR辐射控制的最佳时间段，可显着改善骨骼再生，并且这种由BP组成的NIR触发的药物输送系统适用于需要在特定时间进行精确控制的疗法。