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Green Reduced Graphene Oxide Toughened Semi-IPN Monolith Hydrogel as Dual Responsive Drug Release System: Rheological, Physicomechanical, and Electrical Evaluations
The Journal of Physical Chemistry B ( IF 3.3 ) Pub Date : 2018-07-11 , DOI: 10.1021/acs.jpcb.8b02919
Sayan Ganguly , Poushali Das , Priti Prasanna Maity , Subhadip Mondal , Sabyasachi Ghosh , Santanu Dhara , Narayan Ch. Das

Macroporous hydrogel monoliths having tailor-made features, conductivity, superstretchability, excellent biocompatibility, and biodegradability, have become the most nurtured field of interest in soft biomaterials. Green method assisted reduced graphene oxide has been inserted by in situ free radical gelation into semi-IPN hydrogel matrix to fabricate conducting hydrogel. Mechanical toughness has been implemented for the graphene–polymer physisorption interactions with graphene basal planes. Moreover, the as-prepared 3D scaffold type monolith hydrogel has been rheologically superior regarding their high elastic modulus and delayed gel rupturing. κ-Carragenaan, one of the components of the hydrogel, has biodegradable nature. The most significant outcome is their low electrical percolation threshold and reversibly ductile nature. Reversible ductility provides them with rubber-like consistency in flow conditions. Surprising, the hydrogels showed dual stimuli-responsiveness, that is, environmental pH and external electrical stimulation. Electro-stimulation has been adopted here for the first time in semi-IPN systems, which could be an ideal alternative for iontopheretic devices and pulsatile drug release through skin. Regarding this, the hydrogel also has been passed to biocompatibility assay; they are noncytotoxic and show cell proliferation without negligible cell death in live–dead assay. The porosity of the nanocomposite scaffold-like gels was also analyzed by microcomputed tomography (μ-CT), which exhibited their connectivity in cell/voids inside the matrix. Thus, the experimentations are on the support of biocompatible soft material for dual-responsive tunable drug delivery.

中文翻译:

绿色还原氧化石墨烯增韧半IPN整体水凝胶作为双重响应药物释放系统:流变,物理力学和电学评估

具有定制特征,导电性,超拉伸性,优异的生物相容性和生物降解性的大孔水凝胶整料已成为软生物材料中最受关注的领域。通过原位自由基凝胶化将绿色方法辅助的还原性氧化石墨烯插入半IPN水凝胶基质中,以制备导电水凝胶。对于石墨烯-聚合物与石墨烯基面的物理吸附相互作用,已经实现了机械韧性。而且,所制备的3D支架型整体式水凝胶就其高弹性模量和延迟的凝胶破裂而言在流变学上是优越的。κ-卡拉胶,水凝胶的成分之一,具有可生物降解的性质。最重要的结果是它们的低电渗阈值和可逆延性。可逆的延展性使它们在流动条件下具有橡胶般的稠度。令人惊讶的是,水凝胶显示出双重刺激反应性,即环境pH和外部电刺激。电刺激已在半IPN系统中首次采用,这可能是离子透皮设备和通过皮肤释放脉动药物的理想替代品。关于这一点,水凝胶也已经通过了生物相容性测定。它们无细胞毒性,在活死分析中显示细胞增殖而细胞死亡可忽略不计。纳米复合支架状凝胶的孔隙率也通过微计算机断层扫描(μ-CT)进行了分析,其在基质内部的细胞/空隙中表现出连通性。因此,
更新日期:2018-07-12
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