A diastereo- and enantioselective synthesis of phthalide-oxindole hybrids including congested adjacent quaternary chiral centers was demonstrated through a Lewis base catalyzed asymmetric allylic alkylation reaction of Morita–Baylis–Hillman carbonates of isatins and 3-cyanophthalides. The various hybrid molecules with two valuable pharmacophores-combined frameworks can be obtained in good to high diastereo- and enantioselectivities.

中文翻译：

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邻苯二甲酸季铵盐手性中心通过有机催化的烯丙基烷基化反应生成的非对映体和对映体的高度非对映选择性

通过路易斯碱催化的靛红和3-氰基酞菁的Morita-Baylis-Hillman碳酸盐的不对称烯丙基烷基化反应，证明了邻苯二甲酸酯-羟吲哚杂化物的非对映和对映选择性合成，包括拥挤的相邻四元手性中心。具有良好的至高非对映选择性和对映选择性的具有两种有价值的药效团结合的框架的各种杂合分子。