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Palladium-Catalyzed Oxidative Three-Component Coupling of Anthranilamides with Isocyanides and Arylboronic Acids: Access to 2,3-Disubstituted Quinazolinones
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2018-07-02 00:00:00 , DOI: 10.1021/acs.joc.8b01218
Chun Qian 1, 2 , Kui Liu 1 , Shou-Wei Tao 1 , Fang-Ling Zhang 1 , Yong-Ming Zhu 1 , Shi-Lin Yang 1, 2
Affiliation  

A novel palladium-catalyzed oxidative three-component coupling of easily accessible N-substituted anthranilamides with isocyanides and arylboronic acids is achieved. This protocol offers an alternative approach toward 2,3-disubstituted quinazolinones with a wide substrate scope and good functional group tolerance.

中文翻译:

邻氨基苯甲酰胺与异氰化物和芳基硼​​酸的钯催化氧化三组分偶联:获得2,3-二取代喹唑啉酮的途径

实现了易于获得的N-取代邻氨基苯甲酰胺与异氰化物和芳基硼​​酸的新型钯催化的氧化三组分偶联。该协议为具有较宽的底物范围和良好的官能团耐受性的2,3-二取代的喹唑啉酮提供了另一种方法。
更新日期:2018-07-02
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