An upper-rim functionalized calix[4]arene-based thiourea installed onto the (R,R)-1,2-cyclohexanediamine scaffold was synthesized with a view to investigate its catalytic ability in enantioselective Michael additions. The reactions were found to conveniently proceed under solvent-free conditions, observing good to high enantioselectivities. From this preliminary study, the calix[4]arene unit is likely to play a role in affecting the conversion and to a lesser extent to the stereochemical outcome of the reactions through van der Waals contacts and C–H···π interactions with the substrates.

中文翻译：

---

基于杯芳烃的伯胺硫脲催化的无溶剂对映选择性迈克尔反应

为了研究其在对映选择性迈克尔加成反应中的催化能力，合成了安装在（R，R）-1,2-环己二胺支架上的上边缘功能化杯[4]芳烃基硫脲。发现反应在无溶剂条件下方便地进行，观察到良好至高对映选择性。根据这项初步研究，杯芳烃[4]芳烃单元可能会通过范德华接触和C–H···π相互作用与范德华接触并在较小程度上影响反应的立体化学结果，从而影响转化率。基材。