We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.

中文翻译：

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两种双功能去铁胺螯合剂，用于用锆89 †对生物载体进行生物正交标记

我们报告了两个双功能螯合剂，DFO-Cys和DFO-CBT，根据2-氰基苯并噻唑/ 1,2-氨基硫醇的环加成反应，用锆89标记生物载体。它们的特征是高标记产率，快速有效的生物结合，基于代谢稳定的萤光素的最终产品，以及适用于敏感生物分子的正交两步标记。