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Electrochemical Arylation Reaction
Chemical Reviews ( IF 62.1 ) Pub Date : 2018-07-02 00:00:00 , DOI: 10.1021/acs.chemrev.8b00233
Siegfried R. Waldvogel 1, 2, 3 , Sebastian Lips 1 , Maximilian Selt 1, 2 , Barbara Riehl 1 , Christopher J. Kampf 1, 3
Affiliation  

Arylated products are found in various fields of chemistry and represent essential entities for many applications. Therefore, the formation of this structural feature represents a central issue of contemporary organic synthesis. By the action of electricity the necessity of leaving groups, metal catalysts, stoichiometric oxidizers, or reducing agents can be omitted in part or even completely. The replacement of conventional reagents by sustainable electricity not only will be environmentally benign but also allows significant short cuts in electrochemical synthesis. In addition, this methodology can be considered as inherently safe. The current survey is organized in cathodic and anodic conversions as well as by the number of leaving groups being involved. In some electroconversions the reagents used are regenerated at the electrode, whereas in other electrotransformations free radical sequences are exploited to afford a highly sustainable process. The electrochemical formation of the aryl–substrate bond is discussed for aromatic substrates, heterocycles, other multiple bond systems, and even at saturated carbon substrates. This survey covers most of the seminal work and the advances of the past two decades in this area.

中文翻译:

电化学丙烯酸化反应

芳基化产物存在于化学的各个领域,代表了许多应用的基本实体。因此,这种结构特征的形成代表了当代有机合成的核心问题。通过电的作用,可以部分或什至完全省去离去基团,金属催化剂,化学计量的氧化剂或还原剂的必要性。用可持续的电力代替常规试剂不仅对环境无害,而且在电化学合成中具有明显的捷径。另外,该方法可以被认为本质上是安全的。当前的调查以阴极和阳极转化以及所涉及离去基团的数量进行组织。在某些电转换中,所使用的试剂在电极上再生,而在其他电转化中,利用自由基序列来提供高度可持续的过程。对于芳族底物,杂环,其他多重键系统,甚至饱和碳底物,都讨论了芳基-底物键的电化学形成。这项调查涵盖了该领域的大部分开创性工作以及过去二十年来的进展。
更新日期:2018-07-02
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