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Experimental Design Approach in the Optimization of Potentiometric Method for Lansoprazole Determination Using Lansoprazole-Tungstate Based Ion-Selective Electrode
Industrial & Engineering Chemistry Research ( IF 4.2 ) Pub Date : 2018-07-13 , DOI: 10.1021/acs.iecr.8b01281
Nafisur Rahman 1 , Sumaiya Khan 1
Affiliation  

The PVC membrane immobilized with lansoprazole-tungstate and plasticized with dioctyl phthalate was characterized by FTIR, XRD, and SEM. The effects of critical parameters such as response time, pH, and temperature on the potential were analyzed, and these were optimized using central composite design (CCD) and desirability function. Under the optimized conditions, the plot of measured potential against concentration of lansoprazole exhibited linearity from 2 × 10–5 to 2 × 10–3 mol L–1 at pH 4.4. The slope of the plot and detection limit was −41.50 mV/decade and 1.57 × 10–5 mol L–1, respectively. The response time of the proposed ion-selective electrode was ≤30 s. The electrode exhibited good selectivity for lansoprazole over a number of ionic species, commonly found in commercial dosage forms. The response mechanism was also discussed. The proposed ion-selective electrode was successfully applied for potentiometric determination of lansoprazole.

中文翻译:

兰索拉唑钨酸根离子选择电极用于电位法测定兰索拉唑的实验设计方法

用FTIR,XRD和SEM表征了用兰索拉唑钨酸盐固定并用邻苯二甲酸二辛酯增塑的PVC膜。分析了诸如响应时间,pH和温度等关键参数对电势的影响,并使用中央复合设计(CCD)和合意性函数对这些参数进行了优化。在最佳条件下,测得的电位与兰索拉唑浓度的关系图在pH 4.4下的线性范围为2×10 –5至2×10 –3 mol L –1。曲线的斜率和检出限为−41.50 mV /十倍和1.57×10 –5 mol L –1, 分别。建议的离子选择电极的响应时间≤30 s。电极对兰索拉唑对多种离子物种(在商业剂型中常见)表现出良好的选择性。还讨论了响应机制。所提出的离子选择电极已成功用于兰索拉唑的电位测定。
更新日期:2018-07-14
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