Background: To improve the regenerative capacity of aged individuals, we reconstituted bone marrow (BM) of aged mice with young Sca-1 cells, which repopulated cardiac progenitors and prevented cardiac dysfunction after a myocardial infarction (MI). However, the mechanisms involved were incompletely elucidated. This study aimed to investigate whether young, highly regenerative BM Sca-1 cells exert their cardio-protective effects on the aged heart through reactivation of the epithelial-to-mesenchymal transition (EMT) process.

中文翻译：

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年轻的骨髓 Sca-1 细胞通过促进上皮-间质转化使衰老的心脏恢复活力

背景：为了提高老年个体的再生能力，我们用年轻的 Sca-1 细胞重建了老年小鼠的骨髓 (BM)，这重新填充了心脏祖细胞并预防了心肌梗死 (MI) 后的心功能障碍。然而，所涉及的机制尚未完全阐明。本研究旨在研究年轻、高度再生的 BM Sca-1 细胞是否通过重新激活上皮-间质转化 (EMT) 过程对老年心脏发挥其心脏保护作用。